ORCID
Alison E. Patteson: 0000-0002-4004-1734
Document Type
Article
Date
Fall 9-5-2023
Language
English
Funder(s)
National Institute of General Medical Sciences of the National Institutes of Health and National Science Foundation
Funding ID
R35GM142963 and MCB 2026747
Acknowledgements
This work was supported by the Academy of Finland, Sigrid Juse´lius Foundation, Magnus Ehrnrooth Foundation, the Endowment of the A ° bo Akademi University, K. Albin Johanssons stiftelse,MaudKuistilaMemorialFoundation, Livoch Ha¨lsa Foundation, Otto A Malm Foundation, Finnish Cultural Foundation, Swedish Cultural Foundation, Ella and Georg Ehrnrooth Foundation and the Foundation “Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse”. This work was also supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM142963 and National Science Foundation award number MCB 2026747 granted to AP. We thank Solveig Eriksson for the help with the graphical design. Graphics were created with BioRender.com.
Official Citation
Parvanian S, Coelho-Rato LS, Eriksson JE, Patteson AE. The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions. Curr Opin Cell Biol. 2023 Sep 5;85:102233. doi: 10.1016/j.ceb.2023.102233. Epub ahead of print. PMID: 37677998.
Disciplines
Physics
Description/Abstract
Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.
Recommended Citation
Parvanian S, Coelho-Rato LS, Eriksson JE, Patteson AE. The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions. Curr Opin Cell Biol. 2023 Sep 5;85:102233. doi: 10.1016/j.ceb.2023.102233. Epub ahead of print. PMID: 37677998.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
