ORCID
Areetha D. Souza: 0000-0001-7254-5657
Maryam Ramazani: 0000-0002-5870-3097
Olga Makhlynets: 0000-0002-2763-7891
Alison Patteson: 0000-0002-4004-1734
Document Type
Article
Date
Spring 5-27-2023
Keywords
hydrogel; pH sensitive; antimicrobial; cytocompatible; self-healing; rheology; wound healing
Language
English
Funder(s)
NSF DMR CAREER
Funding ID
2239750
Acknowledgements
Authors thank our summer REU student Reagan Brown, who helped to make some of the peptides discussed, and Jennifer Yoon for her help with the synthesis and LCMS analysis of HHF and FHFH peptides.
Official Citation
Edirisinghe, D.I.U.; D’Souza, A.; Ramezani, M.; Carroll, R.J.; Chicón, Q.; Muenzel, C.L.; Soule, J.; Monroe, M.B.B.; Patteson, A.E.; Makhlynets, O.V. Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel. Molecules 2023, 28, 4390. https://doi.org/10.3390/molecules28114390
Disciplines
Physics
Description/Abstract
A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions of patients each year.
Recommended Citation
Edirisinghe, D.I.U.; D’Souza, A.; Ramezani, M.; Carroll, R.J.; Chicón, Q.; Muenzel, C.L.; Soule, J.; Monroe, M.B.B.; Patteson, A.E.; Makhlynets, O.V. Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel. Molecules 2023, 28, 4390. https://doi.org/10.3390/molecules28114390
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
