Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer
ORCID
Latha Ramalingam: 0000-0002-4856-7327
Document Type
Article
Date
3-2018
Keywords
Breast cancer, Exosomes, Inflammation, N-3 fatty acids, Obesity
Disciplines
Nutrition
Description/Abstract
Obesity is well documented as a risk factor for developing breast cancer, especially in postmenopausal women. Adipose tissue in the breast under obese conditions induces inflammation by increasing macrophage infiltration and pro-inflammatory cytokines that in turn up-regulates genes and signaling pathways, resulting in increased inflammation, cell proliferation and tumor growth in the breast. Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk. Here, we briefly review current status of breast cancer and its relationship with obesity. We then review in depth, current research and knowledge on the role of n-3 PUFA in reducing/preventing breast cancer cell growth in vitro, in vivo and in human studies, and how n-3 PUFA may modulate signaling pathways mitigating their effects on breast cancer development.
Recommended Citation
Al-Jawadi A, Moussa H, Ramalingam L, Dharmawardhane S, Gollahon L, Gunaratne P, Layeequr Rahman R, Moustaid-Moussa N. Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer. J Nutr Biochem. 2018 Mar;53:1-8. doi: 10.1016/j.jnutbio.2017.09.018. Epub 2017 Oct 4. PMID: 29096149.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
