Bound Volume Number
Honors Capstone Project
Date of Submission
Arts and Science
signaling mechanism, Caenorhabditis elegans (C. elegans), GLP-1 signaling
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
Notch signaling is a highly conserved signaling mechanism that is important for many developmental processes in animals. In the roundworm, Caenorhabditis elegans (C. elegans), GLP-1 signaling, a form of Notch signaling, is necessary for mitotic proliferation of the germline. glp-1(ts) mutants display a sterile phenotype at 20 °C. Previously, 14 extragenic suppressors were found that rescued the embryonic and germline temperature sensitive defects caused by improper functioning of GLP in a glp-1(ts) mutant. These mutations were mapped to six genes. These genes are referred to as suppressors of glp-1 or sog mutants. The current study serves to determine the identities of two of these genes, sog-4 and sog-6, at the molecular level using whole genome sequence analyses and RNA interference experiments. Whole genome sequence data support the possibility that sog-4 may correspond oac-49, while RNAi results suggest that sog-4 is not oac-49, a gene whose function is to regulate protein turnover. Both Whole genome sequence data and RNAi data support the possibility that sog-6 may correspond to F28D1.2. Understanding how sog-4 and sog-6 function to regulate the GLP-1/ Notch pathway can give meaningful insight as to how they can be used to regulate diseases that result from improper Notch signaling.
Laing, Micheline, "Understanding the role of sog-4 and sog-6 in the GLP-1/ NOTCH Signaling Pathway" (2016). Syracuse University Honors Program Capstone Projects. 945.
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