Bound Volume Number
Volume II
Degree Type
Honors Capstone Project
Date of Submission
Spring 5-2016
Capstone Advisor
Eleanor Maine
Capstone Major
Biology
Capstone College
Arts and Science
Audio/Visual Component
no
Keywords
signaling mechanism, Caenorhabditis elegans (C. elegans), GLP-1 signaling
Capstone Prize Winner
no
Won Capstone Funding
yes
Honors Categories
Sciences and Engineering
Subject Categories
Biology
Abstract
Notch signaling is a highly conserved signaling mechanism that is important for many developmental processes in animals. In the roundworm, Caenorhabditis elegans (C. elegans), GLP-1 signaling, a form of Notch signaling, is necessary for mitotic proliferation of the germline. glp-1(ts) mutants display a sterile phenotype at 20 °C. Previously, 14 extragenic suppressors were found that rescued the embryonic and germline temperature sensitive defects caused by improper functioning of GLP in a glp-1(ts) mutant. These mutations were mapped to six genes. These genes are referred to as suppressors of glp-1 or sog mutants. The current study serves to determine the identities of two of these genes, sog-4 and sog-6, at the molecular level using whole genome sequence analyses and RNA interference experiments. Whole genome sequence data support the possibility that sog-4 may correspond oac-49, while RNAi results suggest that sog-4 is not oac-49, a gene whose function is to regulate protein turnover. Both Whole genome sequence data and RNAi data support the possibility that sog-6 may correspond to F28D1.2. Understanding how sog-4 and sog-6 function to regulate the GLP-1/ Notch pathway can give meaningful insight as to how they can be used to regulate diseases that result from improper Notch signaling.
Recommended Citation
Laing, Micheline, "Understanding the role of sog-4 and sog-6 in the GLP-1/ NOTCH Signaling Pathway" (2016). Renée Crown University Honors Thesis Projects - All. 945.
https://surface.syr.edu/honors_capstone/945
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