Title

Cisplatin Carbonato Complexes. Implications for Uptake, Antitumor Properties, and Toxicity

Author(s)/Creator(s)

Corey R. Centerwall, Syracuse University
Jerry Goodisman, Syracuse UniversityFollow
Deborah J. Kerwood, Syracuse UniversityFollow
James C. Dabrowiak, Syracuse UniversityFollow

Document Type

Article

Date

5-23-2005

Keywords

Chemistry

Disciplines

Chemistry

Description/Abstract

The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

Additional Information

Reprinted with permission from Centerwall, C. R., Goodisman, J., Kerwood, D. J., & Dabrowiak, J. C. (2005). Cisplatin carbonato complexes. implications for uptake, antitumor properties, and toxicity. Journal of the American Chemical Society, 127(37), 12768-12769. Copyright 2005 American Chemical Society.

http://pubs.acs.org/doi/pdf/10.1021/ja053353c

Recommended Citation

Centerwall, C. R., Goodisman, J., Kerwood, D. J., & Dabrowiak, J. C. (2005). Cisplatin carbonato complexes. implications for uptake, antitumor properties, and toxicity. Journal of the American Chemical Society, 127(37), 12768-12769.

Source

Local Input

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.