Alison E. Patteson: 0000-0002-4004-1734

Document Type



Fall 9-30-2023





Funding ID

NSF CMMI 2238600 and NIH R35GM142963


This work was supported by Academy of Finland, Sigrid Juse´lius Foundation, Magnus Ehrnrooth Foundation, the Endowment of the Abo Akademi University, K. Albin Johanssons stiftelse, Maud Kuistila Memorial Foundation, Liv och Halsa Foundation, Otto A Malm Foundation, Finnish Cultural Foundation, Swedish Cultural Foundation, Ella and Georg Ehrnrooth Foundation, Instrumentariumin tiedesaatio and the Foundation “Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse”. A.P. acknowledges funding from NSF CMMI 2238600 and NIH R35GM142963. We thank Solveig Eriksson for excellent help with the graphical design of the figures. Graphics were created with BioRender.com.

Official Citation

Parvanian S, Coelho-Rato LS, Patteson AE, Eriksson JE. Vimentin takes a hike - Emerging roles of extracellular vimentin in cancer and wound healing. Curr Opin Cell Biol. 2023 Sep 30;85:102246. doi: 10.1016/j.ceb.2023.102246. Epub ahead of print. PMID: 37783033.




Vimentin is a cytoskeletal protein important for many cellular processes, including proliferation, migration, invasion, stress resistance, signaling, and many more. The vimentin-deficient mouse has revealed many of these functions as it has numerous severe phenotypes, many of which are found only following a suitable challenge or stress. While these functions are usually related to vimentin as a major intracellular protein, vimentin is also emerging as an extracellular protein, exposed at the cell surface in an oligomeric form or secreted to the extracellular environment in soluble and vesicle-bound forms. Thus, this review explores the roles of the extracellular pool of vimentin (eVIM), identified in both normal and pathological states. It focuses specifically on the recent advances regarding the role of eVIM in wound healing and cancer. Finally, it discusses new technologies and future perspectives for the clinical application of eVIM.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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