Document Type
Article
Date
Spring 4-14-2021
Language
English
Funder(s)
National Science Foundation, DoD, Syracuse University grant, National Institutes of Health
Funding ID
NSF-DMR-1832002, Isaac Newton Award, U54DK107980, U54CA193419, GM114190
Official Citation
Liu, K., Patteson, A. E., Banigan, E. J., Schwarz, J. M. (2021, April 14). Dynamic nuclear structure emerges from chromatin cross-links and motors. Physical Review Letters. https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.126.158101
Disciplines
Physics
Description/Abstract
The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin protein filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, cross-linked Rouse chain bound to a polymeric shell. System-sized correlated motions occur but require both motor activity and cross-links. Contractile motors, in particular, enhance chromosome dynamics by driving anomalous density fluctuations. Nuclear shape fluctuations depend on motor strength, cross-linking, and chromosome-lamina binding. Therefore, complex chromosome dynamics and nuclear shape emerge from a minimal, active chromosome-lamina system.
Recommended Citation
Liu, K., Patteson, A. E., Banigan, E. J., Schwarz, J. M. (2021, April 14). Dynamic nuclear structure emerges from chromatin cross-links and motors. Physical Review Letters. https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.126.158101
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
