Document Type
Article
Date
8-29-2011
Keywords
condensed matter, soft condensed matter, cell behavior
Language
English
Disciplines
Physics
Description/Abstract
We present a continuum model of the coupling between cells and substrate that accounts for some of the observed substrate-stiffness dependence of cell properties. The cell is modeled as an elastic active gel, adapting recently developed continuum theories of active viscoelastic fluids. The coupling to the substrate enters as a boundary condition that relates the cell's deformation field to local stress gradients. In the presence of activity, the coupling to the substrate yields spatially inhomogeneous contractile stresses and deformations in the cell and can enhance polarization, breaking the cell's front-rear symmetry.
Recommended Citation
arXiv:1106.0929v2
Source
harvested from arXiv.org
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Additional Information
This manuscript is from arXiv.org, there is further information at http://arxiv.org/abs/1106.0929