Bound Volume Number

Volume VIII

Document Type

Honors Capstone Project

Date of Submission

Spring 5-2016

Capstone Advisor

Jeremy Gilbert

Capstone Major

Biomedical and Chemical Engineering

Capstone College

Engineering and Computer Science

Audio/Visual Component

no

Keywords

lectrochemical tests on retrieved inflamed joint fluids

Capstone Prize Winner

no

Won Capstone Funding

no

Honors Categories

Sciences and Engineering

Subject Categories

Biomedical Engineering and Bioengineering | Chemical Engineering

Abstract

There is currently no systematic way to analyze the corrosion response of orthopedic alloys in contact with human joint fluid. The goal of this project was to design and test a small device that can successfully run electrochemical tests on retrieved inflamed joint fluids. Methods of fluid testing analysis were also explored. The a small electrochemical cell was created using polypropylene for the body and an electrode cartridge that could be disposed of after each test. In total the device could hold 4 mL of liquid. Testes were preformed using titanium, stainless steel, and CoCrMo alloys as the working electrodes and were tested in solutions of PBS and AMEM (10% fetal bovine serum) and additions of 0.1 mM of FeCl3 and H2O2 (5, 10, 25 mM) to simulate the inflamed joint fluid created by the oxidative burst reaction. Three electrochemical tests were run to evaluate the cell and included open circuit potential, impedance, and anodic polarization. The results of these tests indicated that the device can be used to analyze the corrosion response of metallic alloys in joint fluid, and that the additions of FeCl3 and H2O2 increased potential of these alloys to corrode.

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

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