Bound Volume Number
Honors Capstone Project
Date of Submission
Biomedical and Chemical Engineering
Engineering and Computer Science
lectrochemical tests on retrieved inflamed joint fluids
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
Biomedical Engineering and Bioengineering | Chemical Engineering
There is currently no systematic way to analyze the corrosion response of orthopedic alloys in contact with human joint fluid. The goal of this project was to design and test a small device that can successfully run electrochemical tests on retrieved inflamed joint fluids. Methods of fluid testing analysis were also explored. The a small electrochemical cell was created using polypropylene for the body and an electrode cartridge that could be disposed of after each test. In total the device could hold 4 mL of liquid. Testes were preformed using titanium, stainless steel, and CoCrMo alloys as the working electrodes and were tested in solutions of PBS and AMEM (10% fetal bovine serum) and additions of 0.1 mM of FeCl3 and H2O2 (5, 10, 25 mM) to simulate the inflamed joint fluid created by the oxidative burst reaction. Three electrochemical tests were run to evaluate the cell and included open circuit potential, impedance, and anodic polarization. The results of these tests indicated that the device can be used to analyze the corrosion response of metallic alloys in joint fluid, and that the additions of FeCl3 and H2O2 increased potential of these alloys to corrode.
Pieri, Kathleen, "Development of an Inflammatory Joint Fluid Corrosion Assessment Method for Metallic Biomaterials" (2016). Honors Capstone Projects - All. 960.
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