Bound Volume Number
Honors Capstone Project
Date of Submission
Prof. Rebecca Bader
Prof. James H. Henderson
Biomedical and Chemical Engineering
Engineering and Computer Science
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
The growing use and investigation of pharmaceuticals to treat disease has offered the field of drug delivery an opportunity to further improve upon the effects provided, as well as address therapeutic complications. An effective long-term treatment for rheumatoid arthritis (RA) has yet be developed, while many current treatments pose disadvantageous side effects due to undesirable reactions outside of the diseased tissue. Therefore, there is a need for an improved strategy for RA treatment. A previously developed drug carrier system based on polysialic acid (PSA) and polycaprolactone (PCL) micelles was shown to be effective for in vitro therapeutic use. The evaluated PSA-PCL micelles were capable of passively accumulating in joint tissue. To actively target diseased tissue, the possibility of improving site specificity through the addition of hyaluronic acid (HA) was explored further here. These micelles were synthesized from separate PSA and PCL polymer conjugates, incorporating HA to the micelle backbone. However, initial characterization revealed large, inconsistent, and unstable micelle structures poorly suited for effective drug delivery. Therefore, additional research is warranted to identify and develop targeted, polysaccharide-based micelles.
Ryan, Weston, "Synthesis and Evaluation of Polysialic Acid-Polycaprolactone Based Micelles for Drug Delivery" (2015). Honors Capstone Projects - All. 907.
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