Bound Volume Number
X
Degree Type
Honors Capstone Project
Date of Submission
Spring 5-5-2015
Capstone Advisor
Prof. Rebecca Bader
Honors Reader
Prof. James H. Henderson
Capstone Major
Biomedical and Chemical Engineering
Capstone College
Engineering and Computer Science
Audio/Visual Component
no
Capstone Prize Winner
no
Won Capstone Funding
no
Honors Categories
Sciences and Engineering
Subject Categories
Therapeutics
Abstract
The growing use and investigation of pharmaceuticals to treat disease has offered the field of drug delivery an opportunity to further improve upon the effects provided, as well as address therapeutic complications. An effective long-term treatment for rheumatoid arthritis (RA) has yet be developed, while many current treatments pose disadvantageous side effects due to undesirable reactions outside of the diseased tissue. Therefore, there is a need for an improved strategy for RA treatment. A previously developed drug carrier system based on polysialic acid (PSA) and polycaprolactone (PCL) micelles was shown to be effective for in vitro therapeutic use. The evaluated PSA-PCL micelles were capable of passively accumulating in joint tissue. To actively target diseased tissue, the possibility of improving site specificity through the addition of hyaluronic acid (HA) was explored further here. These micelles were synthesized from separate PSA and PCL polymer conjugates, incorporating HA to the micelle backbone. However, initial characterization revealed large, inconsistent, and unstable micelle structures poorly suited for effective drug delivery. Therefore, additional research is warranted to identify and develop targeted, polysaccharide-based micelles.
Recommended Citation
Ryan, Weston, "Synthesis and Evaluation of Polysialic Acid-Polycaprolactone Based Micelles for Drug Delivery" (2015). Renée Crown University Honors Thesis Projects - All. 907.
https://surface.syr.edu/honors_capstone/907
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
