Honors Capstone Project
Date of Submission
Arts and Science
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
Biochemistry | Biochemistry, Biophysics, and Structural Biology
Candidiasis, the yeast infection of the mouth, genitals, and blood can be fatal in individuals who are immunocompromised. In humans, Candidiasis is most commonly caused by the yeast, Candida albicans (C. albicans), but can also be caused by other Candida species .
C. albicans demonstrates marked resistance towards Cu(II) but more sensitivity towards Co(II) compounds, especially in mutants that lack the CaCRP1 and CaCUP1 gene that encodes for the copper-transporting P-type ATPase and Metallothionein proteins, respectively. Here, I will describe the effects of Co(II) and Cu(II) metal based complexes that incorporate a bridging pyrophosphate (PPi) moiety.
Currently, we are exploring potential mechanisms of copper resistance and cobalt sensitivity in C. albicans. We hope that in doing so, we can deepen our understanding of the nature of C. albicans sensitivity and shed more light on potential development of therapeutics.
The main focus of this report will focus on the relationship between Co(II) and Cu(II) during in vitro assays of C. albicans clinical isolates to measure growth and metal retention in C. albicans.
Miles, Leann Jade, "Synthesis and Characterization of Co(II) and Cu(II) Pyrophosphate Coordination Complexes for Treatment of Pathogenic Agents." (2014). Syracuse University Honors Program Capstone Projects. 769.
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