Degree Type
Honors Capstone Project
Date of Submission
Spring 5-1-2014
Capstone Major
Biology
Capstone College
Arts and Science
Audio/Visual Component
no
Capstone Prize Winner
no
Won Capstone Funding
yes
Honors Categories
Sciences and Engineering
Subject Categories
Biochemistry | Biochemistry, Biophysics, and Structural Biology
Abstract
Candidiasis, the yeast infection of the mouth, genitals, and blood can be fatal in individuals who are immunocompromised. In humans, Candidiasis is most commonly caused by the yeast, Candida albicans (C. albicans), but can also be caused by other Candida species .[1]
C. albicans demonstrates marked resistance towards Cu(II) but more sensitivity towards Co(II) compounds, especially in mutants that lack the CaCRP1 and CaCUP1 gene that encodes for the copper-transporting P-type ATPase and Metallothionein proteins, respectively.[2] Here, I will describe the effects of Co(II) and Cu(II) metal based complexes that incorporate a bridging pyrophosphate (PPi) moiety.
Currently, we are exploring potential mechanisms of copper resistance and cobalt sensitivity in C. albicans. We hope that in doing so, we can deepen our understanding of the nature of C. albicans sensitivity and shed more light on potential development of therapeutics.
The main focus of this report will focus on the relationship between Co(II) and Cu(II) during in vitro assays of C. albicans clinical isolates to measure growth and metal retention in C. albicans.
Recommended Citation
Miles, Leann Jade, "Synthesis and Characterization of Co(II) and Cu(II) Pyrophosphate Coordination Complexes for Treatment of Pathogenic Agents." (2014). Renée Crown University Honors Thesis Projects - All. 769.
https://surface.syr.edu/honors_capstone/769
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
