Honors Capstone Project
Date of Submission
Martin Forstner Assistant Professor of Physics at Syracuse University
Daniel Needleman Associate Professor of Applied Physics at Harvard University
Arts and Science
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
Biology | Genetic Phenomena | Physics
In my Renee Crown Honors Capstone project, I studied how genetic variation influences birth defects that cause death in C. elegans embryos. I performed high-throughput hatching assay experiments of recombinant inbred advance intercross lines of C. elegans. These lines are genetically distinct from each other. I found significant variation in birth defects causing embryo death in these recombinant inbred advanced intercross lines. My results give evidence that gene interaction may play a significant role in causing birth defects resulting in death. My data also provides a starting point for studies making statistical arguments linking these birth defects to specific genetic interactions.
Kepple, Daniel Robert, "Influence of Genetic Variation on Birth Defects in Caenorhabditis elegans" (2013). Honors Capstone Projects - All. 65.
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