Degree Type
Honors Capstone Project
Date of Submission
Spring 5-1-2013
Capstone Advisor
Martin Forstner Assistant Professor of Physics at Syracuse University
Honors Reader
Daniel Needleman Associate Professor of Applied Physics at Harvard University
Capstone Major
Physics
Capstone College
Arts and Science
Audio/Visual Component
no
Capstone Prize Winner
no
Won Capstone Funding
yes
Honors Categories
Sciences and Engineering
Subject Categories
Biology | Genetic Phenomena | Physics
Abstract
In my Renee Crown Honors Capstone project, I studied how genetic variation influences birth defects that cause death in C. elegans embryos. I performed high-throughput hatching assay experiments of recombinant inbred advance intercross lines of C. elegans. These lines are genetically distinct from each other. I found significant variation in birth defects causing embryo death in these recombinant inbred advanced intercross lines. My results give evidence that gene interaction may play a significant role in causing birth defects resulting in death. My data also provides a starting point for studies making statistical arguments linking these birth defects to specific genetic interactions.
Recommended Citation
Kepple, Daniel Robert, "Influence of Genetic Variation on Birth Defects in Caenorhabditis elegans" (2013). Renée Crown University Honors Thesis Projects - All. 65.
https://surface.syr.edu/honors_capstone/65
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
