Document Type

Honors Capstone Project

Date of Submission

Spring 5-1-2008

Capstone Advisor

John D. Chisholm, Ph. D

Honors Reader

Michael Sponsler, Ph. D

Capstone Major

Chemistry

Capstone College

Arts and Science

Audio/Visual Component

no

Capstone Prize Winner

no

Won Capstone Funding

no

Honors Categories

Sciences and Engineering

Subject Categories

Chemistry

Abstract

Ligand effects play an important role in reactivity and selectivity in many transition metal catalyzed processes. The role of the phosphine ligand is critical to the product ratio in rhodium-catalyzed reaction of methyl vinyl ketone and terminal alkynes. For a ligand with a hemilabile oxygen on the phosphine, smaller ligands shift the product ratio in favor of the 1,4-addition product while with bulky oxygen ligands a dimerization/addition product manifold is dominant. Ligand screen results show that tri-o-tolylphosphine (TOTP) provided the best yields and highest selectivity for dimer-addition product.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Included in

Chemistry Commons

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