Degree Type
Honors Capstone Project
Date of Submission
Spring 5-1-2008
Capstone Advisor
John D. Chisholm, Ph. D
Honors Reader
Michael Sponsler, Ph. D
Capstone Major
Chemistry
Capstone College
Arts and Science
Audio/Visual Component
no
Capstone Prize Winner
no
Won Capstone Funding
no
Honors Categories
Sciences and Engineering
Subject Categories
Chemistry
Abstract
Ligand effects play an important role in reactivity and selectivity in many transition metal catalyzed processes. The role of the phosphine ligand is critical to the product ratio in rhodium-catalyzed reaction of methyl vinyl ketone and terminal alkynes. For a ligand with a hemilabile oxygen on the phosphine, smaller ligands shift the product ratio in favor of the 1,4-addition product while with bulky oxygen ligands a dimerization/addition product manifold is dominant. Ligand screen results show that tri-o-tolylphosphine (TOTP) provided the best yields and highest selectivity for dimer-addition product.
Recommended Citation
Marquez, Jocellie, "The Ligand Effects in the Rhodium Catalyzed 1,4-Addition Reaction of Terminal Alkynes to -Unsaturated Ketones" (2008). Renée Crown University Honors Thesis Projects - All. 528.
https://surface.syr.edu/honors_capstone/528
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