Degree Type
Honors Capstone Project
Date of Submission
Spring 5-1-2012
Capstone Advisor
Professor Karin Ruhlandt
Honors Reader
Professor Jon Zubieta
Capstone Major
Biology
Capstone College
Arts and Science
Audio/Visual Component
no
Capstone Prize Winner
no
Won Capstone Funding
no
Honors Categories
Sciences and Engineering
Subject Categories
Biochemistry | Biochemistry, Biophysics, and Structural Biology
Abstract
The purpose of this project is to study synthetic methodologies leading to the designing of various calcium and magnesium based diphosphonates with possible applications as bone scaffolding materials. In tissue engineering scaffolds are frequently employed to enhance the growth of new cells, providing the motivation to study alkaline earth metal based diphosphonates as a possible source for scaffold for bone growth.
While the transition metal phosphonates based frameworks are well studied, alkaline earth metal based phosphonates and diphosphonates remain at its infancy. The challenge to the chemistry of the alkaline earth metal phosphonates and diphosphonates based frameworks includes poor solubility of compounds and limited understanding on how to control the metal’s coordination environment. The main difference between alkaline earth and transition metals lies in the nature of the metal-ligand bond, as well as the size of the metal center. Whereas metal-ligand bonding in the transition metals is dictated by the metal’s d-orbital that not only provide a robust bond, but also maintain geometrical control; the alkaline earth metal-ligand bond is predominantly electrostatic, as such, many parameters dictate the metal environment. Often, multiple configurations that are very similar in energy are possible.
The main focus of this project was to synthesize desired diphosphonate ligand and to design and establish suitable conditions to grow high quality crystals to be analysed with single X-ray diffraction. Among number of available methods such as hydrothermal, solvothermal and gel crystallisation, this project mainly employed hydrothermal method to produce designed crystals.
A further aspect of this project was to synthesize 3-oxapentane-1,5-biphosponic acid and to produce magnesium and calcium based frameworks. This study provides a sequential step to synthesise the ligand.
Recommended Citation
Suh, Seungmo, "Synthesis and Structural Studies of Calcium and Magnesium Diphosphonate Compounds" (2012). Honors Capstone Projects - All. 151.
https://surface.syr.edu/honors_capstone/151
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