Date of Award

1-24-2024

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Biomedical and Chemical Engineering

Advisor(s)

Mary Beth Monroe

Second Advisor

Zhao Qin

Keywords

Antibiofilm;Antimicrobial;Antioxidant;Phenolic acids;Shape memory polymer;Trauma

Abstract

Severe trauma causes 5 million deaths annually worldwide, 30-40% of which are due to uncontrolled bleeding. Of these, 39% of trauma wounds develop polymicrobial infections, and even if the patient can be treated in the hospital, the patient is at significant risk of contracting drug-resistant bacteria. Therefore, we developed dual incorporated phenolic acid (DPA)-based shape memory polymer (SMP) foam as a hemostatic agent. In emergencies, this DPA-based SMP foam can be injected into the deep wound to rapidly stop bleeding and disinfect the wound to prevent hemorrhage and wound infection. Additionally, when the patient is exposed in the hospital, this DPA-based SMP foam prevents infection with drug-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA) and promotes wound healing treatment through reactive oxygen species (ROS) scavenging. In conclusion, this hemostatic agent can be used as an emergency hemostatic agent as well as a wound dressing during treatment and is multifunctional by introducing different types of phenolic acids such as p-coumaric acid, ferulic acid, and vanillic acid. Furthermore, we have developed a variety of PA-based adhesive antimicrobial biomaterials for wound treatment, such as sprays, solutions, and powders, through PA polymerization reactions In my dissertation, I focused on the antimicrobial, antioxidant, and procoagulant properties of phenolic acid's researching mainly p-coumaric acid, ferulic acid, and vanillic acid. As well as the applications of these phenolic acids in biomaterials mainly shape memory polymer foams.

Access

Open Access

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Available for download on Friday, January 17, 2025

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