Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes
Date of Award
Doctor of Philosophy (PhD)
Doyle, Robert P.
Chemistry | Physical Sciences and Mathematics
This thesis addresses several questions focused on the activation of receptors expressed withinthe area postrema (AP) and the nucleus tractus solitarius (NTS), regions known to influence nausea and emesis. Prevention of such effects were achieved via corrination, covalent attachment to vitamin B12 (B12) or other corrin constructs, of GLP glucagon-like peptide-one (GLP-1) receptor (GLP-1R) agonists or via the use of GRASP a growth differentiation factor 15 (GDF15) glial derived neurotropic family receptor α-like (GFRAL) complex antagonist.
Tinsley, Ian, "Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes" (2021). Dissertations - ALL. 1432.