Date of Award
Summer 7-16-2021
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
Advisor(s)
Doyle, Robert P.
Subject Categories
Chemistry | Physical Sciences and Mathematics
Abstract
This thesis addresses several questions focused on the activation of receptors expressed withinthe area postrema (AP) and the nucleus tractus solitarius (NTS), regions known to influence nausea and emesis. Prevention of such effects were achieved via corrination, covalent attachment to vitamin B12 (B12) or other corrin constructs, of GLP glucagon-like peptide-one (GLP-1) receptor (GLP-1R) agonists or via the use of GRASP a growth differentiation factor 15 (GDF15) glial derived neurotropic family receptor α-like (GFRAL) complex antagonist.
Access
Open Access
Recommended Citation
Tinsley, Ian, "Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes" (2021). Dissertations - ALL. 1432.
https://surface.syr.edu/etd/1432
