Date of Award
Master of Science (MS)
Nutrition Science and Dietetics
Fish oil, Insulin resistance, Obesity
This study investigates the effects of fish oil in father male mice and how it could potentially affect skeletal muscle health of the next generation. Thirty male mice were fed either a low fat diet (LF), High-Fat Diet (HF), and a High-Fat diet supplemented with fish oil (FO) for 10 weeks to mimic paternal obesity. They were then mated with female mice on chow diet and all mice consumed chow diet during gestation and lactation. Offspring mice were supplemented with chow diet for 16 weeks and half of the mice were sacrificed at 8-weeks and rest at 16-weeks to study the short-term and long-term effect of FO respectively. Results showed that the 8-week offspring born to father fed FO had significant upregulation of genetic markers associated with insulin signaling, and skeletal muscle growth and down regulation of genetic markers of fatty acid synthesis. These findings suggest potential benefits of paternal supplementation of fish oil to compensate for a long-term exposure of HF.
Xiong, Ligeng, "Role of Fish Oil in Paternal Obesity and in Offspring Skeletal Muscle Health" (2023). Theses - ALL. 712.