Date of Award
Master of Science (MS)
Biomedical and Chemical Engineering
Mary Beth Monroe
Degradable shape memory polymers, Hemostatic device, Polyurethane hemocompatibility, Shape memory polymers
Biomedical Engineering and Bioengineering | Engineering
Shape memory polymer (SMP) foams are a class of smart materials that show promise for managing uncontrolled hemorrhage on the battlefield. The current standard treatments of gauze and tourniquets are not able to effectively control hemorrhage in up to 80% of combat injuries. Most hemostatic devices also require removal within 12 hours of application. Patient transportation to a facility for removal may not be possible within this time frame and the removal process itself can cause further damage to the wound. As an alternative hemostatic device, polyurethane SMP foams have shown to be effective and biocompatible hemostats; however, removal still remains a concern. Degradable SMP foams have been developed through modification of a previously tested polyurethane SMP system to overcome this limitation. In this work, in vitro hemocompatibility and overall blood interactions with these degradable SMP foams is assessed. The primary outcome of these studies shows that the polyurethane SMP foams maintain hemocompatibility with incorporation of specific degradable components. The data collected here will aid in further development of this degradable SMP system as well assist future in vitro and in vivo studies leading into clinical trials of this SMP system for hemostatic applications.
Shepherd, Ellen Barlow, "Blood-material Interactions With Degradable Shape Memory Polymer Foams" (2021). Theses - ALL. 493.