Date of Award

May 2020

Degree Type

Dissertation/Thesis

Degree Name

Master of Science (MS)

Department

Biomedical and Chemical Engineering

Advisor(s)

Mary B. Monroe

Keywords

3D Modeling, Grade V Injury, Hemorrhaging, In Vitro Model, Pressure, Shape Memory Polymers

Subject Categories

Engineering

Abstract

Shape memory polymer foam hemostats are a promising option for future hemorrhage control in battlefield wounds. To enable their use as hemostatic devices they must be optimized in terms of formulation and architecture and characterized in terms of safety and efficacy. As a device advances through the stages of development, pre-clinical testing is required in animals. In order to help mitigate the excess use of animals as well as decrease the costs of pre-clinical research, relevant in vitro models need to be created and used for device optimization. In the work conducted here, two in vitro models were created; a simplified gunshot wound model and a grade V liver injury model were constructed and used for the testing of a variety of shape memory polymer foam hemostat geometries. The primary outcomes included how foam geometry affected wall pressures and hemorrhaging of the simulated blood. This work assisted in narrowing down hemostat design options based on the inflicted wound. After testing, the 8 different foam hemostat geometries pros and cons were elucidated, which will help to minimize future animal testing.

Access

Open Access

Available for download on Sunday, August 15, 2021

Included in

Engineering Commons

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