Date of Award

December 2019

Degree Name

Master of Science (MS)

Department

Biomedical and Chemical Engineering

Advisor(s)

Mary B. Monroe

Keywords

antimicrobial, antioxidant, IC50, log reduction, phenolic acid, shape memory polymer

Subject Categories

Engineering

Abstract

Shape memory polymer (SMP) foams provide a promising new option for hemorrhage control on the battlefield; however, they lack a mechanism to control wound infections that can delay healing processes. Adding phenolic acids (PAs) into SMP foams provides a natural, non-drug option for incorporations of antioxidant and antimicrobial functionalities that may promote healing. However, PAs lack a systemic characterization of their structure/property relationships, and their chemical incorporation into SMP foams may alter their efficacy. In this work, a library of PAs was screened in terms of antioxidant and antimicrobial properties to provide a full understanding of how their structure affects their function. Additionally, a subset of PAs was modified with SMP foam analog monomers (modified PAs, MPAs) and compared to their unmodified counterparts. PA and MPA antioxidant capabilities were tested in terms of hydrogen peroxide scavenging capacity, and their antimicrobial activities were evaluated against both gram-positive and gram-negative bacteria strains. After testing, the PA library was narrowed down from 10 to 5 candidates with the best solubility, antioxidant properties, and antimicrobial properties. These PAs will be added into SMP foams for use in antimicrobial hemostats.

Access

Open Access

Available for download on Saturday, January 09, 2021

Included in

Engineering Commons

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