Date of Award

May 2019

Degree Name

Master of Science (MS)

Department

Biomedical and Chemical Engineering

Advisor(s)

Zhen Ma

Keywords

alignment, cardiomyocyte, shape memory polymer, surface topography

Subject Categories

Engineering

Abstract

In the previous work, it has been proven that substrate topography can influent the cell behaviors, including morphology and functions. Many research teams showed that wrinkled surfaces have been able to improve the alignment and orientation of different biological cell types. Cardiomyocytes are also influenced by the surface topography with better alignment along the winkles, comparing to the flat surface. However, there is little evidence to demonstrate how cardiomyocytes would respond to the wrinkle formation and achieve the cellular alignment change during the transition from flat surface to topographic surface. In this thesis, we have created a dynamic substrate based on shape memory polymer to change the surface topography and induce the nanoscale wrinkle formation. Using this dynamic substrate, we can observe the cardiomyocyte responses to topography changes, and investigate the dynamic reorganization progress of myofibril remodeling during the cell alignment.

Access

Open Access

Included in

Engineering Commons

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