Title

Synthesis and Structural Characterization of Mn(II) and Co(II) Pyrophosphate Complexes with 1,10-phenanthroline-5,6-dione

Date of Award

December 2017

Degree Name

Master of Science (MS)

Department

Chemistry

Advisor(s)

Robert P. Doyle

Second Advisor

Jon A. Zubieta

Keywords

biology, Cobalt, magnetics, Manganese, Mycobacterium tuberculosis, phendione

Subject Categories

Physical Sciences and Mathematics

Abstract

The overall goal of this research is to synthesize and characterize new Mn(II) and Co(II) complexes with phendione as a terminal ligand and pyrophosphate as a capping or bridging ligand. We would like to produce Mn(II) and Co(II) compounds that: 1) are aqueously soluble to test for activity against Mycobacterium tuberculosis (M. tb); 2); contain multinuclear metal centers to test for magnetic properties and 3) offer open coordination sites to test for their catalytic activity in ketone oxidations. Chapter 2 focuses on the synthesis and characterization of Mn(II) complexes with phendione and their activity against M. tb as well magnetic properties of one Mn(II) complex. Two Co(II) complexes with phendione were synthesized, characterized and tested for magnetic susceptibility, described in Chapter 3. The synthesis and characterization of new Mn(II) and Co(II) complexes with phendione allow us to gain insight on the effect of the phendione ligand on targeting M. tb, the electronics of magnetic systems, and catalytic activity of the coordination complexes discussed in Chapter 7.

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