Honors Capstone Project
Date of Submission
Mary Lou Vallano
Arts and Science
Capstone Prize Winner
Won Capstone Funding
Sciences and Engineering
Biology | Laboratory and Basic Science Research | Neuroscience and Neurobiology
In January 2010, I started work as an undergraduate research assistant at SUNY Upstate Medical University in Dr. Mary Lou Vallano’s laboratory in the Department of Neuroscience and Physiology. My research project was part of a collaborative effort with the laboratory of Dr. Eric Deshaies, a vascular neurosurgeon at Upstate. The goal was to establish a rodent model of subarachnoid hemorrhage and delayed vasospasm, and to test possible protective strategies. We used an adult rat model, in which two injections of autologous blood were given in the cisterna magna region of the brain. Analysis was done using a combination of histology, immunohistochemistry, and molecular biology to examine vasospasm in the basilar artery, and changes in the surrounding neural tissues. Based on Dr. Deshaies’ patient information and clinical work, we examined whether exercise preconditioning or the injection of stannous chloride would decrease the inflammatory response and the occurrence or intensity of vasospasm. Our results indicate that the model is working, and they point to the possible protective effect of stannous chloride.
Wendel, Sarah Katherine Jane, "Modeling Hemorrhagic Stroke and Vasospasm in the Rodent" (2011). Syracuse University Honors Program Capstone Projects. 256.
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