Document Type

Article

Date

5-2010

Embargo Period

4-29-2013

Keywords

Raman; in vivo; blood analysis; glucose; noninvasive

Disciplines

Chemistry

Description/Abstract

We probe volar-side fingertip capillary beds with nearinfrared laser light and collect Raman, Rayleigh, and Mie scattered light and fluorescence. The results are interpreted using radiation transfer theory in the single-scattering approximation. The surface topography of the skin is modeled using the Fresnel equations. The skin is treated as a three-layer material, with a mean-field treatment of tissue composition and related optical properties. The model, with a reasonable choice of tissue parameters, gives a remarkably accurate account of the features of actual measurements. It predicts the optimal values for the incident angle of the laser beam and the distance between beam and detector. It explains the correlated temporal changes in the intensities of elastically and inelastically scattered light caused by heart-driven pulses and why they are out of phase. With appropriate boundary conditions, the model can be used to discuss the scattering from ridged skin extruded conformally into an aperture in a metal surface under constant light pressure. The probing results suggest an inherent regularity and similarity in the anatomy and composition of surface and subsurface tissues of a wide range of skin types.

Additional Information

Copyright 2010 Journal of Biomedical Optics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and Journal of Biomedical Optics.

The article may be found at http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1103433

Source

local input

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Included in

Chemistry Commons

Share

COinS