Date of Award

Spring 5-15-2022

Degree Type


Degree Name

Master of Science (MS)


Biomedical and Chemical Engineering


Jain, Era

Subject Categories

Chemical Engineering | Engineering


Trauma or repeated injury to the joint can result in focal cartilage defects, which significantly increase the risk of osteoarthritis. Cartilage being avascular has limited self-healing capacity. The current method for treating cartilage defects at early stages involves implantation of autologous chondrocytes with or without a scaffold through invasive surgery; however, invasive surgery can bring pain to patients and post-operative infection risks. Therefore, injectable and biodegradable biomaterials have piqued people's interest. In the current research, we designed a hybrid double network (DN) cryogel by combining multi-arm PEG acrylate and alginate as two networks and crosslinking them at -20°C. Through different characterizations (SEM, mechanical strength, swelling test, etc.), we found that the DN cryogel has a macroporous interconnected structure, high water uptake capacity, and can support chondrocyte growth and extracellular matrix synthesis. These features make it possible for the cryogel to be used as a scaffold for cartilage to treat cartilage defects.

Key words: Cartilage defect, double network cryogels, macroporous interconnectionstructure


Open Access



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