Date of Award

Spring 5-23-2021

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Biomedical and Chemical Engineering

Advisor(s)

Monroe, Mary Beth

Keywords

Degradable shape memory polymers, Hemostatic device, Polyurethane hemocompatibility, Shape memory polymers

Subject Categories

Biomedical Engineering and Bioengineering | Engineering

Abstract

Shape memory polymer (SMP) foams are a class of smart materials that show promise for managing uncontrolled hemorrhage on the battlefield. The current standard treatments of gauze and tourniquets are not able to effectively control hemorrhage in up to 80% of combat injuries. Most hemostatic devices also require removal within 12 hours of application. Patient transportation to a facility for removal may not be possible within this time frame and the removal process itself can cause further damage to the wound. As an alternative hemostatic device, polyurethane SMP foams have shown to be effective and biocompatible hemostats; however, removal still remains a concern. Degradable SMP foams have been developed through modification of a previously tested polyurethane SMP system to overcome this limitation. In this work, in vitro hemocompatibility and overall blood interactions with these degradable SMP foams is assessed. The primary outcome of these studies shows that the polyurethane SMP foams maintain hemocompatibility with incorporation of specific degradable components. The data collected here will aid in further development of this degradable SMP system as well assist future in vitro and in vivo studies leading into clinical trials of this SMP system for hemostatic applications.

Access

Open Access

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.