Synthesis and Characterization of Calcium Arylphosphonate Metal Organic Frameworks

Date of Award


Degree Name

Master of Science (MS)




Karin Ruhlandt


Calcium phosphonates

Subject Categories



The quest for bioactive and biocompatible materials for bone therapy is of growing importance, as currently used materials display significant limitations. Our work is utilizing bisphosphonates, a chemical entity used in common drugs to treat bone disorders, in combination with calcium to obtain biocompatible and bioactive three-dimensional metal organic frameworks (MOFs). The main challenge of this project remains in the synthesis of said calcium phosphonate target compounds. The absence of energetically favorabledorbitals and the large metal diameter in calcium make for weak metal-ligand bonds; both are well-known challenges for obtaining X-ray quality crystals. The work presented describes synthetic conditions for the synthesis of novel calcium phosphonates. Utilizing ligands with different substitution patterns allowed for a better comprehension of the effect of the ligand topology on the overall geometry of the resulting framework.

This thesis will discuss recent results of two novel calcium phosphonate compounds focusing on variables such as (i) the substitution pattern of the phosphonate moieties on the aryl; (ii) reaction conditions including: pH, temperature, solvent, and stoichiometry and (iii) their effect on the overall geometry of the new materials. Lastly, a structural comparison between known complexes and the novel obtained complexes is provided.


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