Date of Award

August 2020

Degree Type


Degree Name

Master of Science (MS)


Biomedical and Chemical Engineering


Zhen Ma


Cardiomyocyte, Dynamic substrate, Focal adhesion, Mechanobiology, Shape memory polymer

Subject Categories



Focal adhesions are the large molecular complexes that anchor cells to the ECM, which is involved in cell spreading, migration, and proliferation. In our previous work, the study of cardiomyocyte morphological changes and myofibril remodeling, responding to the dynamic nano-topographic substrate, have been accomplished. The results showed focal adhesion experienced disassembly and reassembly in the first 12 hours. In this study, the hiPSC-CMs were seeded on the SMP substrates with the flat-to-wrinkle dynamic surface. Paxillin, vinculin, and zyxin from different layers of focal adhesive architectures were co-stained with F-actin. The fluorescent images were analyzed to investigate the details of focal adhesions remodeling and the dynamics of costameres in the first stage post triggering the substrate wrinkle formation.


Open Access

Included in

Engineering Commons



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