Prescription medication misuse is a long-term population health problem in the United States. This data slice uses data from the National Wellbeing Survey (N=32,789, 2021–2025) of U.S. adults ages 18–64 to examine how the number of chronic health conditions a person has is related to their misuse of prescription opioids, tranquilizers, sedatives, or stimulants in the past 12 months. The authors find a dose-response pattern: misuse rises from 2.8% among those with no chronic conditions to 11.7% among those with three or more conditions. Mental health conditions show stronger associations with misuse than physical health conditions.
