Document Type
Article
Date
5-2010
Keywords
Raman; in vivo; blood analysis; glucose; noninvasive
Disciplines
Chemistry
Description/Abstract
We probe volar-side fingertip capillary beds with nearinfrared laser light and collect Raman, Rayleigh, and Mie scattered light and fluorescence. The results are interpreted using radiation transfer theory in the single-scattering approximation. The surface topography of the skin is modeled using the Fresnel equations. The skin is treated as a three-layer material, with a mean-field treatment of tissue composition and related optical properties. The model, with a reasonable choice of tissue parameters, gives a remarkably accurate account of the features of actual measurements. It predicts the optimal values for the incident angle of the laser beam and the distance between beam and detector. It explains the correlated temporal changes in the intensities of elastically and inelastically scattered light caused by heart-driven pulses and why they are out of phase. With appropriate boundary conditions, the model can be used to discuss the scattering from ridged skin extruded conformally into an aperture in a metal surface under constant light pressure. The probing results suggest an inherent regularity and similarity in the anatomy and composition of surface and subsurface tissues of a wide range of skin types.
Recommended Citation
Goodisman, Jerry and Chaiken, Joseph, "On probing human fingertips in vivo using near-infrared light: model calculations" (2010). Chemistry - All Scholarship. 95.
https://surface.syr.edu/che/95
Source
local input
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Additional Information
Copyright 2010 Journal of Biomedical Optics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and Journal of Biomedical Optics.
The article may be found at http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1103433