Document Type

Article

Date

5-23-2005

Embargo Period

3-20-2013

Keywords

Chemistry

Disciplines

Chemistry

Description/Abstract

The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

Additional Information

Reprinted with permission from Centerwall, C. R., Goodisman, J., Kerwood, D. J., & Dabrowiak, J. C. (2005). Cisplatin carbonato complexes. implications for uptake, antitumor properties, and toxicity. Journal of the American Chemical Society, 127(37), 12768-12769. Copyright 2005 American Chemical Society.

http://pubs.acs.org/doi/pdf/10.1021/ja053353c

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This work is licensed under a Creative Commons Attribution 3.0 License.

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