Document Type

Article

Date

1989

Embargo Period

9-29-2010

Keywords

Caenorhabditis elegans, cell-cell interaction, cell fate, glp-1, lin-12

Language

English

Disciplines

Biology

Description/Abstract

Cell-cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans. It has been found that two genes, glp-1 and lin-12, are required for many of these decisions. glp-1 is required for induction of mitotic proliferation in the germline by the somatic distal tip cell and for induction of the anterior pharynx early in embryogenesis. lin-12 is required for the interactions between cells of equivalent developmental potential, which allow them to take on different fates. Comparison of these two genes on a molecular level indicates that they are similar in sequence and organization, suggesting that the mechanisms of these two different sets of cell-cell interactions are similar.

Source

University of Wisconsin-Madison

Creative Commons License


This work is licensed under a Creative Commons Attribution 3.0 License.

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Biology Commons

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